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CS-W001157 4
Total: USD 88.00

2-Amino-3-chloropyridine

  • CAS No. 39620-04-7

  • Cat. No. CS-W003089
  • Purity≥98%
  • MDL No.MFCD03541052

*For research and further manufacturing use only, not for direct human use.

2-Amino-3-chloropyridine|CS-W003089

Structure of 39620-04-7

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General Information

  • CAS No. 39620-04-7
  • Cat. No. CS-W003089
  • Purity ≥98%
  • MDL No. MFCD03541052
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₂
  • Molecular Weight 128.56
  • Synonym(s) OTAVA-BB BB7110951381
  • SMILES Clc1cccnc1N

Application

2-Amino-3-chloropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via palladium-catalyzed cross-coupling reactions. Its amino group facilitates nucleophilic substitution and condensation reactions, while the chloro substituent offers high reactivity in Suzuki, Stille, and Buchwald–Hartwig couplings. Bench-stable and readily purified by recrystallization, it functions efficiently in the synthesis of pyridine-based pharmaceutical intermediates and heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • BAYER PHARMACEUTICALS CORPORATION Patent: WO2006/44775 A2, 2006 ; Location in patent: Page/Page column 64 ;
  • Route2

    References

    • Gudmundsson, Kristjan S.; Johns, Brian A. Organic Letters, 2003 , vol. 5, # 8 p. 1369 - 1372
  • Route3

    References

    • den Hertog et al. Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.3172
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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