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Structure of 54231-32-2
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3-Chloro-2-nitropyridine features a nitro group at the 2-position and a chloro substituent at the 3-position on the pyridine ring, creating a highly electron-deficient heterocycle. This combination enables selective nucleophilic substitution reactions under mild conditions, facilitating efficient coupling with diverse amines and thiols. The molecule exhibits excellent stability during handling and storage, making it a reliable building block for pharmaceutical intermediates and functional materials synthesis.
3-Chloro-2-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the C3 position via nucleophilic substitution. The nitro group at C2 enhances electrophilicity at adjacent positions and facilitates subsequent reduction to an amine for further derivatization. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions make it a practical choice for constructing complex pyridine-based scaffolds in medicinal chemistry and agrochemical research.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: