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CS-W001157 4
Total: USD 88.00

3-Chloro-2-nitropyridine

  • CAS No. 54231-32-2

  • Cat. No. CS-W008191
  • Purity≥97%
  • MDL No.MFCD00490110
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Chloro-2-nitropyridine|CS-W008191

Structure of 54231-32-2

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Description

3-Chloro-2-nitropyridine features a nitro group at the 2-position and a chloro substituent at the 3-position on the pyridine ring, creating a highly electron-deficient heterocycle. This combination enables selective nucleophilic substitution reactions under mild conditions, facilitating efficient coupling with diverse amines and thiols. The molecule exhibits excellent stability during handling and storage, making it a reliable building block for pharmaceutical intermediates and functional materials synthesis.

Application

3-Chloro-2-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the C3 position via nucleophilic substitution. The nitro group at C2 enhances electrophilicity at adjacent positions and facilitates subsequent reduction to an amine for further derivatization. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions make it a practical choice for constructing complex pyridine-based scaffolds in medicinal chemistry and agrochemical research.

General Information

  • CAS No. 54231-32-2
  • Cat. No. CS-W008191
  • Purity ≥97%
  • MDL No. MFCD00490110
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight 158.54
  • Synonym(s) 3-Chloro-2-Nitro Pyridine
  • SMILES O=[N+](C1=NC=CC=C1Cl)[O-]

Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.6432
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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