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CS-W001157 4
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4-Aminopyridin-2(1H)-one

  • CAS No. 38767-72-5

  • Cat. No. CS-0058663
  • Purity≥98%
  • MDL No.MFCD09832889

*For research and further manufacturing use only, not for direct human use.

4-Aminopyridin-2(1H)-one|CS-0058663

Structure of 38767-72-5

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General Information

  • CAS No. 38767-72-5
  • Cat. No. CS-0058663
  • Purity ≥98%
  • MDL No. MFCD09832889
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O
  • Molecular Weight 110.11
  • Synonym(s) 4-Aminopyridin-2-ol
  • SMILES O=C1NC=CC(N)=C1

Description

4-Aminopyridin-2(1H)-one features a fused pyridone core with a strategically positioned amino group, enabling strong hydrogen bonding and enhanced solubility. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in kinase inhibitors and antiviral agents. The compound exhibits robust stability under standard bench conditions and facilitates efficient derivatization via amine functionalization.

Application

4-Aminopyridin-2(1H)-one serves as a versatile scaffold in medicinal chemistry, enabling rapid access to diverse heterocyclic systems through its dual functionality: a nucleophilic amine and a hydrogen-bond-capable carbonyl. It functions as a key building block in the synthesis of kinase inhibitors and other bioactive molecules, offering excellent bench stability, straightforward purification, and compatibility with standard coupling and cyclization protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.88
  • LogP   -0.0429
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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