2-Amino-4-hydroxypyridine

Name: 2-Amino-4-hydroxypyridine
Brand: ChemScene
Availability: InStock
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CAS No. 33631-05-9
Cat. No. CS-D0773
Purity≥95%
MDL No.MFCD04114161

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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General Information

CAS No. 33631-05-9
Cat. No. CS-D0773
Purity ≥95%
MDL No. MFCD04114161
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆N₂O
Molecular Weight None
Synonym(s) 2-Aminopyridin-4-ol
SMILES OC1=CC(N)=NC=C1

Description

2-Amino-4-hydroxypyridine features a fused heterocyclic scaffold with strategically positioned amino and hydroxyl groups, enabling robust hydrogen bonding and enhanced solubility. This arrangement supports its role as a key intermediate in bioactive molecule synthesis, particularly within kinase inhibitor scaffolds and nucleoside analogs.

Application

2-Amino-4-hydroxypyridine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through established coupling and cyclization protocols. Its dual functionality—amine and hydroxyl groups—facilitates selective derivatization, protecting group strategies, and metal-catalyzed transformations. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows in API development.

Synthesis

Route1
- In-stock
  
  19798-80-2
- ~58%
- In-stock
  
  33631-05-9
References
- Journal of Medicinal Chemistry, , vol. 52, # 19 p. 5793 - 5802
Route2
- 1026394-00-2
- ~%
- In-stock
  
  33631-05-9
References
- Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 59.14
LogP 0.3694
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Amino-4-hydroxypyridine

CAS No. 33631-05-9

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