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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6-methylnicotinonitrile

  • CAS No. 38367-36-1

  • Cat. No. CS-M2974
  • Purity≥98%
  • MDL No.MFCD11847537

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-methylnicotinonitrile|CS-M2974

Structure of 38367-36-1

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General Information

  • CAS No. 38367-36-1
  • Cat. No. CS-M2974
  • Purity ≥98%
  • MDL No. MFCD11847537
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄Cl₂N₂
  • Molecular Weight 187.03
  • Synonym(s) 3-Pyridinecarbonitrile, 2,4-dichloro-6-methyl-
  • SMILES ClC1=NC(C)=CC(Cl)=C1C#N

Description

2,4-Dichloro-6-methylnicotinonitrile features a trifunctional pyridine core bearing two chlorine substituents and a nitrile group at the 6-position. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a key intermediate in medicinal chemistry, where its steric and electronic profile supports targeted derivatization.

Application

2,4-Dichloro-6-methylnicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of substituted pyridine scaffolds. Its ortho-chloro groups facilitate palladium-catalyzed cross-coupling reactions, while the nitrile and methyl functionalities offer sites for selective transformations. The compound exhibits good bench stability and compatibility with common reaction conditions, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • 4-Hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide|CS-0670054
      68373-65-9
    • ~%
    • In-stock
      2,4-Dichloro-6-methylnicotinonitrile|CS-M2974
      38367-36-1

    References

    • ICI Australia Limited Patent: US4631081 A1, 1986 ;
  • Route2

    References

    • Azuma, Yutaka; Morone, Mieko; Nagayama, Kouki; Kawamata, Yurie; Sato, Atsuko Heterocycles, 2003 , vol. 60, # 6 p. 1461 - 1468
  • Route3

    References

    • Azuma, Yutaka; Morone, Mieko; Nagayama, Kouki; Kawamata, Yurie; Sato, Atsuko Heterocycles, 2003 , vol. 60, # 6 p. 1461 - 1468

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   2.5685
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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