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CS-W001157 4
Total: USD 88.00

Lenalidomide-6-F

  • CAS No. 2468780-87-0

  • Cat. No. CS-0173160
  • Purity≥96%
  • MDL No.MFCD34169277

*For research and further manufacturing use only, not for direct human use.

Lenalidomide-6-F|CS-0173160

Structure of 2468780-87-0

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General Information

  • CAS No. 2468780-87-0
  • Cat. No. CS-0173160
  • Purity ≥96%
  • MDL No. MFCD34169277
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₁FN₂O₃
  • Molecular Weight 262.24
  • Synonym(s) None
  • SMILES O=C(C(N(CC1=C2C=C(F)C=C1)C2=O)CC3)NC3=O

Description

Lenalidomide-6-F exhibits enhanced metabolic stability and improved solubility compared to parent lenalidomide, enabling more consistent performance in cellular assays. The fluorinated derivative integrates readily into kinase inhibition studies and serves as a robust probe for targeted protein degradation workflows under standard conditions.

Application

Lenalidomide-6-F serves as a fluorinated analog of lenalidomide, enabling targeted exploration of structure-activity relationships in immunomodulatory drug development. The 6-fluoro substitution enhances metabolic stability and modulates electronic properties, facilitating improved binding affinity in target engagement studies. This compound functions as a valuable synthetic intermediate for probing cereblon-binding interactions and supports the construction of advanced heterocyclic scaffolds in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.48
  • LogP   0.0398
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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