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CS-W001157 4
Total: USD 88.00

(5-(Trifluoromethyl)pyridin-2-yl)boronic acid

  • CAS No. 1162257-58-0

  • Cat. No. CS-W018365
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-(Trifluoromethyl)pyridin-2-yl)boronic acid|CS-W018365

Structure of 1162257-58-0

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General Information

  • CAS No. 1162257-58-0
  • Cat. No. CS-W018365
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BF₃NO₂
  • Molecular Weight 190.92
  • Synonym(s) 5-(Trifluoromethyl)pyridine-2-boronic acid
  • SMILES FC(C1=CN=C(B(O)O)C=C1)(F)F

Description

This boronate moiety features a trifluoromethyl-substituted pyridine scaffold, delivering enhanced electron deficiency and improved stability under standard conditions. The para-positioned trifluoromethyl group imparts strong inductive withdrawal, facilitating efficient cross-coupling reactions while maintaining bench-stable handling characteristics.

Application

(5-(Trifluoromethyl)pyridin-2-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. Its trifluoromethylpyridine core imparts enhanced metabolic stability and modulated electronic properties, making it valuable for medicinal chemistry applications. The boronic acid functionality offers good bench stability, compatibility with diverse reaction conditions, and straightforward purification via aqueous workup.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.2198
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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