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2-Amino-3,3,3-trifluoropropan-1-ol hydrochloride

  • CAS No. 1196154-75-2

  • Cat. No. CS-0167664
  • Molecule weight165.54
  • Purity≥95%
  • MDL No.MFCD10697731

*For research and further manufacturing use only, not for direct human use.

2-Amino-3,3,3-trifluoropropan-1-ol hydrochloride|CS-0167664

Structure of 1196154-75-2

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General Information

  • CAS No. 1196154-75-2
  • Cat. No. CS-0167664
  • Purity ≥95%
  • MDL No. MFCD10697731
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇ClF₃NO
  • Molecular Weight 165.54
  • Synonym(s) 2-AMINO-3,3,3-TRIFLUOROPROPAN-1-OL HCL
  • SMILES OCC(N)C(F)(F)F.Cl

Description

This trifluorinated amino alcohol hydrochloride delivers a polar, bench-stable scaffold with enhanced solubility and metabolic stability. The electron-withdrawing trifluoromethyl group modulates reactivity, while the protonated amine enables efficient salt formation for purification and formulation. Ideal for medicinal chemistry campaigns requiring bioavailable, fluorinated building blocks.

Application

2-Amino-3,3,3-trifluoropropan-1-ol hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated amino alcohols with enhanced metabolic stability. Its trifluoromethyl group imparts strong electron-withdrawing character and improved lipophilicity, while the primary amine and hydroxyl functionalities offer orthogonal reactivity for conjugation or derivatization. The hydrochloride salt enhances bench stability and solubility, facilitating handling in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.2901
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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