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CS-W001157 4
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5-Fluoropyridin-2-ylboronic acid

  • CAS No. 946002-10-4

  • Cat. No. CS-0053148
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluoropyridin-2-ylboronic acid|CS-0053148

Structure of 946002-10-4

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General Information

  • CAS No. 946002-10-4
  • Cat. No. CS-0053148
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BFNO₂
  • Molecular Weight 140.91
  • Synonym(s) 5-Fluoropyridine-2-boronic acid
  • SMILES OB(O)C1=NC=C(F)C=C1

Description

5-Fluoropyridin-2-ylboronic acid features a boronic acid group conjugated to a fluorinated pyridine ring, enabling robust coupling in Suzuki-Miyaura reactions. This electron-deficient heterocycle integrates readily into complex molecular architectures, offering enhanced reactivity and stability under standard conditions.

Application

5-Fluoropyridin-2-ylboronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its fluorinated pyridine core provides enhanced metabolic stability and tunable electronic properties, making it particularly valuable in medicinal chemistry and agrochemical synthesis. The boronic acid functionality offers excellent bench stability, compatibility with diverse reaction partners, and straightforward purification via crystallization or chromatography.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -1.0995
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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