1-Propanamine, 2,2-difluoro-, hydrochloride

Name: 1-Propanamine, 2,2-difluoro-, hydrochloride
Brand: ChemScene
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CAS No. 868241-48-9
Cat. No. CS-0028374
Purity≥96%
MDL No.MFCD06659051

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Propanamine, 2,2-difluoro-, hydrochloride|CS-0028374

Structure of 868241-48-9

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General Information

CAS No. 868241-48-9
Cat. No. CS-0028374
Purity ≥96%
MDL No. MFCD06659051
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₈ClF₂N
Molecular Weight 131.55
Synonym(s) 2,2-DIFLUOROPROPAN-1-AMINE HCL
SMILES NCC(F)(F)C.[H]Cl

Description

2,2-Difluoropropylamine hydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a geminal difluoro substitution that imparts enhanced metabolic stability. This fluorinated alkylamine integrates readily into bioactive molecules, serving as a key building block for pharmaceutical intermediates and functionalized polymers where lipophilicity and resistance to oxidative degradation are critical.

Application

2,2-Difluoropropylamine hydrochloride serves as a valuable building block for fluorinated bioactive molecules, enabling the introduction of a stable, lipophilic difluoromethyl group into pharmaceutical and agrochemical scaffolds. Its bench-stable nature and compatibility with standard amine functionalization protocols facilitate efficient synthesis of target compounds via nucleophilic substitution or reductive amination.

Synthesis

Route1
- 1017241-19-8
- ~%
- In-stock
  
  868241-48-9
References
- Dow, Robert L.; Carpino, Philip A.; Hadcock, John R.; Black, Shawn C.; Iredale, Philip A.; DaSilva-Jardine, Paul; Schneider, Steven R.; Paight, Ernest S.; Griffith, David A.; Scott, Dennis O.; O'Connor, Rebecca E.; Nduaka, Chudy I. Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2652 - 2655

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 26.02
LogP 1.0221
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

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1-Propanamine, 2,2-difluoro-, hydrochloride

CAS No. 868241-48-9

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