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CS-W001157 4
Total: USD 88.00

2-Chloro-1,3-difluorobenzene

  • CAS No. 38361-37-4

  • Cat. No. CS-W018183
  • Purity≥97%
  • MDL No.MFCD00142604

*For research and further manufacturing use only, not for direct human use.

2-Chloro-1,3-difluorobenzene|CS-W018183

Structure of 38361-37-4

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General Information

  • CAS No. 38361-37-4
  • Cat. No. CS-W018183
  • Purity ≥97%
  • MDL No. MFCD00142604
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClF₂
  • Molecular Weight 148.54
  • Synonym(s) CHLORO-2,6-DIFLUOROBENZENE
  • SMILES FC1=C(Cl)C(F)=CC=C1

Description

2-Chloro-1,3-difluorobenzene features a trifunctional aromatic core with strategically positioned chlorine and fluorine substituents, enabling precise tuning of electronic and steric properties. This bench-stable compound integrates readily into synthetic routes requiring orthogonal reactivity or enhanced metabolic stability.

Application

2-Chloro-1,3-difluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated aromatic motifs. Its ortho-chloro and meta-fluoro substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and electrophilic substitution. Bench-stable and readily purified by distillation, it functions effectively in Suzuki-Miyaura, Negishi, and Buchwald-Hartwig reactions, offering predictable regioselectivity and compatibility with common protecting groups.

Synthesis

  • Route1
    • null|null
      372-18-9
    • ~74%
    • In-stock
      2-Chloro-1,3-difluorobenzene|CS-W018183
      38361-37-4

    References

    • Heiss, Christophe; Rausis, Thierry; Schlosser, Manfred Synthesis, 2005 , # 4 art. no. T11504SS, p. 617 - 621
  • Route2

    References

    • Pews, R. Garth; Gall, James A. Journal of Fluorine Chemistry, 1991 , vol. 53, # 3 p. 379 - 386
  • Route3
    • 2,3,4-Trichlorobenzenesulfonyl chloride|CS-0204862
      34732-09-7
    • ~%
    • In-stock
      2-Chloro-1,3-difluorobenzene|CS-W018183
      38361-37-4

    References

    • Moore Jr., Robert M. Organic Process Research and Development, 2003 , vol. 7, # 6 p. 921 - 924

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.6182
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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