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CS-W001157 4
Total: USD 88.00

1-Chloro-2,3-difluorobenzene

  • CAS No. 36556-47-5

  • Cat. No. CS-W021314
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Chloro-2,3-difluorobenzene|CS-W021314

Structure of 36556-47-5

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General Information

  • CAS No. 36556-47-5
  • Cat. No. CS-W021314
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClF₂
  • Molecular Weight 148.54
  • Synonym(s) 2,3-Difluorochlorobenzene
  • SMILES FC1=C(F)C(Cl)=CC=C1

Description

1-Chloro-2,3-difluorobenzene is a fluorinated aromatic compound featuring ortho-fluorine and chlorine substituents on a benzene ring. This configuration imparts enhanced metabolic stability and electron-deficient character, enabling efficient incorporation into pharmaceutical intermediates and agrochemical scaffolds via palladium-catalyzed cross-coupling reactions. The molecule exhibits favorable solubility in common organic solvents and maintains stability under standard bench conditions.

Application

1-Chloro-2,3-difluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The ortho-fluorine substituents enhance metabolic stability and modulate electronic properties, while the chloro group provides a reliable handle for selective functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for iterative synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1
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      360-47-4
    • null|null
      356-96-7
    • ~%
    • In-stock
      4-Chloro-1,2-difluorobenzene|CS-W013302
      696-02-6
    • In-stock
      1-Chloro-2,3-difluorobenzene|CS-W021314
      36556-47-5

    References

    • EP285324 B1, ;
  • Route2

    References

    • Journal of Fluorine Chemistry, , vol. 53, # 3 p. 379 - 386
  • Route3

    References

    • Journal of Fluorine Chemistry, , vol. 53, # 3 p. 379 - 386

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.6182
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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