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CS-W001157 4
Total: USD 88.00

4,4'-Sulfonylbis(fluorobenzene)

  • CAS No. 383-29-9

  • Cat. No. CS-W010189
  • Purity≥98%
  • MDL No.MFCD00000350

*For research and further manufacturing use only, not for direct human use.

4,4'-Sulfonylbis(fluorobenzene)|CS-W010189

Structure of 383-29-9

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General Information

  • CAS No. 383-29-9
  • Cat. No. CS-W010189
  • Purity ≥98%
  • MDL No. MFCD00000350
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈F₂O₂S
  • Molecular Weight 254.25
  • Synonym(s) Bis(p-fluorophenyl) sulfone
  • SMILES C2=C([S](C1=CC=C(F)C=C1)(=O)=O)C=CC(=C2)F

Description

4,4'-Sulfonylbis(fluorobenzene) features a rigid, electron-deficient aromatic scaffold that facilitates efficient coupling reactions in cross-coupling and polymerization processes. This bench-stable compound integrates seamlessly into high-performance materials design, offering enhanced thermal stability and controlled reactivity under standard conditions.

Application

4,4'-Sulfonylbis(fluorobenzene) serves as a versatile bifunctional building block in the synthesis of sulfonamide-linked biaryls and functionalized polymers. Its dual fluorophenyl groups enable efficient Suzuki-Miyaura coupling, while the sulfonyl linker provides rigidity and enhanced solubility. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative coupling strategies in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Konishi Chemical Industry Co., Ltd. Patent: US4558161 A1, 1985 ;
  • Route2

    References

    • Lee, Hong Geun; Milner, Phillip J.; Buchwald, Stephen L. Organic Letters, 2013 , vol. 15, # 21 p. 5602 - 5605
  • Route3
    • null|null
      462-06-6
    • In-stock
      4-Fluorobenzenesulfonyl chloride|CS-W008916
      349-88-2
    • ~89%
    • In-stock
      4,4'-Sulfonylbis(fluorobenzene)|CS-W010189
      383-29-9

    References

    • Garzya, Vincenzo; Forbes, Ian T.; Lauru, Stephanie; Maragni, Paolo Tetrahedron Letters, 2004 , vol. 45, # 7 p. 1499 - 1501

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   2.7976
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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