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CS-W001157 4
Total: USD 88.00

4-Fluorobenzenesulfonyl chloride

  • CAS No. 349-88-2

  • Cat. No. CS-W008916
  • Purity≥97%
  • MDL No.MFCD00007438

*For research and further manufacturing use only, not for direct human use.

4-Fluorobenzenesulfonyl chloride|CS-W008916

Structure of 349-88-2

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General Information

  • CAS No. 349-88-2
  • Cat. No. CS-W008916
  • Purity ≥97%
  • MDL No. MFCD00007438
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClFO₂S
  • Molecular Weight 194.61
  • Synonym(s) 4-Fluorobenzene-1-sulfonyl chloride; 4-Fluorophenylsulfonyl chloride
  • SMILES O=S(C1=CC=C(F)C=C1)(Cl)=O

Description

4-Fluorobenzenesulfonyl chloride delivers a highly reactive sulfonylating agent featuring a fluorinated aromatic ring that enhances electrophilicity and improves solubility in organic solvents. This bench-stable reagent enables efficient formation of sulfonamide and sulfonate derivatives under mild conditions, offering enhanced selectivity in complex molecular architectures.

Application

4-Fluorobenzenesulfonyl chloride serves as a reliable sulfonylating agent for the synthesis of sulfonamide derivatives, offering high reactivity with amines and alcohols under mild conditions. Its fluorinated aryl group enhances stability and facilitates purification via crystallization or chromatography. The compound functions effectively in the construction of bioactive scaffolds and is compatible with diverse functional groups, making it a practical choice for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.7532
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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