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CS-W001157 4
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2-Fluoro-6-hydroxybenzaldehyde

  • CAS No. 38226-10-7

  • Cat. No. CS-W007917
  • Purity≥98%
  • MDL No.MFCD01090996

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-hydroxybenzaldehyde|CS-W007917

Structure of 38226-10-7

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General Information

  • CAS No. 38226-10-7
  • Cat. No. CS-W007917
  • Purity ≥98%
  • MDL No. MFCD01090996
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FO₂
  • Molecular Weight 140.11
  • Synonym(s) 2-Fluor-6-Hydroxybenzaldehyde
  • SMILES FC1=C(C=O)C(=CC=C1)O

Description

2-Fluoro-6-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by fluorine and hydroxyl substituents, enabling direct incorporation into diverse synthetic scaffolds. This electron-deficient aromatic core supports efficient derivatization under mild conditions, particularly in cross-coupling and condensation reactions. The hydroxyl functionality enhances solubility and provides a handle for further functionalization.

Application

2-Fluoro-6-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling direct introduction of fluorine and hydroxyl functionality adjacent to an aldehyde group. Its reactivity facilitates nucleophilic addition, electrophilic substitution, and coupling reactions under standard conditions. The molecule exhibits bench stability and enables straightforward purification via recrystallization or column chromatography, supporting its use in the synthesis of heterocyclic scaffolds and functionalized aromatic intermediates.

Synthesis

  • Route1

    References

    • FUJISAWA PHARMACEUTICAL CO., LTD Patent: WO2004/45610 A1, 2004 ; Location in patent: Page/Page column 137-138 ; WO 2004/045610 A1
  • Route2
    • 5-Fluoro-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one|CS-1193592
      888958-32-5
    • ~69%
    • In-stock
      2-Fluoro-6-hydroxybenzaldehyde|CS-W007917
      38226-10-7

    References

    • Bajwa, Naval; Jennings, Michael P. Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3646 - 3649
  • Route3
    • null|null
      199388-02-8
    • ~98%
    • In-stock
      2-Fluoro-6-hydroxybenzaldehyde|CS-W007917
      38226-10-7

    References

    • Zacharie, Boulos; Attardo, Giorgio; Barriault, Nancy; Penney, Christopher Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 19 p. 2925 - 2929

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.3438
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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