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Structure of 136516-64-8
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2,4-Difluoro-6-hydroxybenzaldehyde features a uniquely reactive aldehyde group flanked by two fluorine atoms and a phenolic hydroxyl, enabling direct functionalization in late-stage synthesis. The electron-withdrawing fluorines enhance electrophilicity at the carbonyl carbon, while the ortho-hydroxy functionality supports chelation or intramolecular stabilization. This combination facilitates efficient coupling reactions under mild conditions, particularly in pharmaceutical intermediates and bioconjugation workflows.
2,4-Difluoro-6-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated aromatic scaffolds with orthogonal functionality. The aldehyde group facilitates efficient imine formation and reductive amination, while the phenolic hydroxyl supports derivatization via etherification or esterification. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses requiring controlled regioselectivity and functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: