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CS-W001157 4
Total: USD 88.00

4-Fluorosalicylaldehyde

  • CAS No. 348-28-7

  • Cat. No. CS-W008001
  • Purity≥97%
  • MDL No.MFCD03788526

*For research and further manufacturing use only, not for direct human use.

4-Fluorosalicylaldehyde|CS-W008001

Structure of 348-28-7

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General Information

  • CAS No. 348-28-7
  • Cat. No. CS-W008001
  • Purity ≥97%
  • MDL No. MFCD03788526
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FO₂
  • Molecular Weight None
  • Synonym(s) Benzaldehyde, 4-fluoro-2-hydroxy-
  • SMILES FC1=CC=C(C(=C1)O)C=O

Description

4-Fluorosalicylaldehyde features a fluorinated aromatic ring paired with adjacent aldehyde and hydroxyl groups, enabling robust coordination in metal complexes. The electron-withdrawing fluorine enhances electrophilicity at the carbonyl carbon, facilitating nucleophilic addition reactions. This bench-stable compound integrates readily into ligand frameworks for catalysis and materials synthesis.

Application

4-Fluorosalicylaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling efficient synthesis of bioactive heterocycles and functionalized aromatics. Its ortho-hydroxy and aldehyde functionalities facilitate direct condensation reactions, chelation, and metal coordination, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it ideal for iterative synthetic workflows.

Synthesis

  • Route1
    • null|null
      50-00-0
    • In-stock
      3-Fluorophenol|CS-W020028
      372-20-3
    • ~73%
    • In-stock
      4-Fluorosalicylaldehyde|CS-W008001
      348-28-7

    References

    • PHARMACIA CORPORATION Patent: WO2004/87686 A2, 2004 ; Location in patent: Page 504 ; Title/Abstract Full Text Show Details PHARMACIA CORPORATION Patent: WO2004/87687 A1, 2004 ; Location in patent: Page 504 ; WO 2004/087687 A1
  • Route2
    • In-stock
      3-Fluorophenol|CS-W020028
      372-20-3
    • null|null
      75-05-8
    • ~55%
    • In-stock
      4-Fluorosalicylaldehyde|CS-W008001
      348-28-7

    References

    • Wang, Jizhou; Ma, Chunlong; Wang, Jun; Jo, Hyunil; Canturk, Belgin; Fiorin, Giacomo; Pinto, Lawrence H.; Lamb, Robert A.; Klein, Michael L.; DeGrado, William F. Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2804 - 2812
  • Route3

    References

    • Journal of the Chemical Society, , p. 1639

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.3438
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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