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CS-W001157 4
Total: USD 88.00

6-Methylsalicylaldehyde

  • CAS No. 18362-36-2

  • Cat. No. CS-W006529
  • Purity≥98%
  • MDL No.MFCD16038308

*For research and further manufacturing use only, not for direct human use.

6-Methylsalicylaldehyde|CS-W006529

Structure of 18362-36-2

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General Information

  • CAS No. 18362-36-2
  • Cat. No. CS-W006529
  • Purity ≥98%
  • MDL No. MFCD16038308
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₂
  • Molecular Weight 136.15
  • Synonym(s) 2-Hydroxy-6-methylbenzaldehyde
  • SMILES OC1=CC=CC(C)=C1C=O

Description

6-Methylsalicylaldehyde features a methyl-substituted salicylaldehyde scaffold with a reactive aldehyde group and phenolic hydroxyl, enabling efficient coordination in metal complexation and serving as a key building block for chelating ligands.

Application

6-Methylsalicylaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to biologically relevant heterocycles and metal-chelating ligands. Its ortho-hydroxy aldehyde functionality facilitates intramolecular cyclizations and coordination with transition metals, while the methyl substituent enhances electronic modulation and metabolic stability. Bench-stable and amenable to standard purification methods, it functions reliably in coupling reactions, condensation processes, and scaffold elaboration for medicinal chemistry applications.

Synthesis

  • Route1

    References

    • Pu; Scripko; Huang Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 12 p. 1183 - 1191
  • Route2
    • null|null
      67-66-3
    • null|null
      108-39-4
    • ~26%
    • In-stock
      6-Methylsalicylaldehyde|CS-W006529
      18362-36-2
    • In-stock
      4-Hydroxy-2-methylbenzaldehyde|CS-W005254
      41438-18-0

    References

    • Komiyama, Makoto; Hirai, Hidefumi Journal of the American Chemical Society, 1983 , vol. 105, # 7 p. 2018 - 2021
  • Route3
    • null|null
      50-00-0
    • null|null
      108-39-4
    • ~6%
    • In-stock
      6-Methylsalicylaldehyde|CS-W006529
      18362-36-2
    • In-stock
      2-Hydroxy-4-methylbenzaldehyde|CS-W007888
      698-27-1

    References

    • Payne, Peter; Tyman, John H. P.; Mehet, Satinder K.; Ninagawa, Akira Journal of Chemical Research, 2006 , # 6 p. 402 - 405

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.51312
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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