Lot numbers can be found on the outside label of a product:
Methyl 2-amino-4,6-difluorobenzoate
-
CAS No. 379228-57-6
- Cat. No. CS-0042662
- Purity≥98%
- MDL No.MFCD12159819
*For research and further manufacturing use only, not for direct human use.
Structure of 379228-57-6
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 379228-57-6
- Cat. No. CS-0042662
- Purity ≥98%
- MDL No. MFCD12159819
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₇F₂NO₂
- Molecular Weight 187.14
- Synonym(s) Methyl 2,4-difluoro-6-aminobenzoate
- SMILES O=C(OC)C1=C(F)C=C(F)C=C1N
Description
Methyl 2-amino-4,6-difluorobenzoate features a strategically positioned amino group flanked by two fluorine atoms, enabling enhanced electronic modulation in synthetic intermediates. This bench-stable compound integrates readily into pharmaceutical and agrochemical scaffolds, offering high reactivity under standard coupling conditions.
Application
Methyl 2-amino-4,6-difluorobenzoate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocycles and bioactive scaffolds. The ortho-amino group facilitates direct functionalization or cyclization, while the difluoro substitution pattern enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by column chromatography, it participates reliably in Pd-catalyzed cross-couplings and amide bond formations, making it well-suited for iterative synthesis workflows in API development.
Synthesis
-
Route1
-
In-stock
126674-77-9 -
67-56-1 - ~86%
-
In-stock
379228-57-6
References
-
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
-
-
Route2
-
In-stock
126674-77-9
-
77-78-1
- ~66%
-
In-stock
379228-57-6
References
-
Ford, J. Gair; Pointon, Simon M.; Powell, Lyn; Siedlecki, Paul S.; Baum, John; Chubb, Richard; Fieldhouse, Robin; Muxworthy, James; Nivlet, Alex; Stenson, Rachel; Warwick, Eleanor Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1078 - 1087
-
-
Route3
-
In-stock
126674-93-9 - ~%
-
In-stock
379228-57-6
References
-
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 52.32
- LogP 1.3336
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- Methyl 2-amino-4,6-difluorobenzoate sigmaMethyl 2-amino-4,6-difluorobenzoate manufacturerMethyl 2-amino-4,6-difluorobenzoate priceMethyl 2-amino-4,6-difluorobenzoate structureMethyl 2-amino-4,6-difluorobenzoate SDSbuy Methyl 2-amino-4,6-difluorobenzoateMethyl 2-amino-4,6-difluorobenzoate supplierMethyl 2-amino-4,6-difluorobenzoate usesMethyl 2-amino-4,6-difluorobenzoate molecular weightprice of Methyl 2-amino-4,6-difluorobenzoateMethyl 2-amino-4,6-difluorobenzoate chemical name formula of Methyl 2-amino-4,6-difluorobenzoate