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Structure of 126674-77-9
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2-Amino-4,6-difluorobenzoic acid features a strategically positioned amino group flanked by two fluorine atoms, delivering enhanced electron-withdrawing effects and improved metabolic stability. This combination enables direct incorporation into bioactive scaffolds, particularly in kinase inhibitor development and medicinal chemistry campaigns requiring high binding affinity and solubility under physiological conditions.
2-Amino-4,6-difluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via amide coupling or Ullmann-type transformations. The ortho-amino and meta-fluoro substituents provide orthogonal reactivity for late-stage functionalization, while the carboxylic acid group facilitates conjugation to peptide or heterocyclic systems. Bench-stable and compatible with standard purification protocols, it functions reliably in multi-step syntheses targeting kinase inhibitors and CNS-targeted therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: