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CS-W001157 4
Total: USD 88.00

3-Amino-5-(tert-butyl)phenol

  • CAS No. 3791-00-2

  • Cat. No. CS-0590522
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Amino-5-(tert-butyl)phenol|CS-0590522

Structure of 3791-00-2

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General Information

  • CAS No. 3791-00-2
  • Cat. No. CS-0590522
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO
  • Molecular Weight 165.23
  • Synonym(s) 3-Amino-5-tert.-butyl-phenol
  • SMILES NC1=CC(O)=CC(C(C)(C)C)=C1

Description

3-Amino-5-(tert-butyl)phenol features a sterically hindered tert-butyl group that enhances stability and solubility in organic media. The ortho-amino functionality enables direct incorporation into amide couplings and metal-ligand architectures. This phenolic scaffold delivers robust performance under standard bench conditions, facilitating efficient access to functionalized intermediates in pharmaceutical and materials synthesis.

Application

3-Amino-5-(tert-butyl)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a sterically hindered phenolic scaffold with ortho-amino functionality. Its stability under standard reaction conditions enables reliable use in Suzuki-Miyaura couplings, amide formations, and electrophilic substitutions. The tert-butyl group enhances solubility and metabolic resistance, while the amino and hydroxyl groups provide orthogonal handles for sequential functionalization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   2.2719
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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