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CS-W001157 4
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Bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(0)

  • CAS No. 1233717-68-4

  • Cat. No. CS-0080495
  • Purity≥95%
  • MDL No.MFCD15071402

*For research and further manufacturing use only, not for direct human use.

Bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(0)|CS-0080495

Structure of 1233717-68-4

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General Information

  • CAS No. 1233717-68-4
  • Cat. No. CS-0080495
  • Purity ≥95%
  • MDL No. MFCD15071402
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₂H₅₆N₂P₂Pd
  • Molecular Weight 637.17
  • Synonym(s) Pd(A-taPhos)2
  • SMILES [Pd][P](C(C)(C)C)(C(C)(C)C)C1=CC=C(N(C)C)C=C1

Description

Bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(0) is a bench-stable, electron-rich palladium(0) complex featuring sterically shielded phosphine ligands that enhance catalyst longevity and promote efficient coupling in cross-coupling reactions under mild conditions.

Application

Bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(0) serves as a highly effective, bench-stable precatalyst for cross-coupling reactions. Its sterically protected phosphine ligands enhance catalyst longevity and resistance to oxidation, enabling reliable performance in Suzuki, Stille, and Negishi couplings. The dimethylamino groups improve solubility and electronic modulation, facilitating efficient transmetalation and reductive elimination under mild conditions. This complex is particularly valuable for constructing biaryl and heterocyclic scaffolds in medicinal chemistry and materials synthesis, offering predictable reactivity and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   4.1866
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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