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CS-W001157 4
Total: USD 88.00

2-(Aminomethyl)benzofuran

  • CAS No. 37798-05-3

  • Cat. No. CS-0186434
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Aminomethyl)benzofuran|CS-0186434

Structure of 37798-05-3

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General Information

  • CAS No. 37798-05-3
  • Cat. No. CS-0186434
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO
  • Molecular Weight 147.17
  • Synonym(s) BENZOFURAN-2-YLMETHANAMINE
  • SMILES C1=CC=C2C(=C1)C=C(CN)O2

Description

2-(Aminomethyl)benzofuran is a versatile heterocyclic scaffold featuring a benzofuran core linked to a primary amine via a methylene bridge. This configuration enables direct functionalization in medicinal chemistry and materials science, offering enhanced solubility and synthetic handle access under standard conditions.

Application

2-(Aminomethyl)benzofuran serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant scaffolds. The pendant primary amine facilitates conjugation reactions, while the benzofuran core provides structural rigidity and favorable pharmacokinetic properties. It exhibits good bench stability and compatibility with standard functional group manipulations, making it suitable for modular synthesis of target molecules in drug discovery campaigns.

Synthesis

  • Route1
    • null|null
      114354-16-4
    • ~21%
    • In-stock
      2-(Aminomethyl)benzofuran|CS-0186434
      37798-05-3

    References

    • Ube Industries, Ltd. Patent: EP2264009 A1, 2010 ; Location in patent: Page/Page column 104 ;
  • Route2
    • null|null
      1261025-22-2
    • ~21%
    • In-stock
      2-(Aminomethyl)benzofuran|CS-0186434
      37798-05-3

    References

    • Ube Industries, Ltd. Patent: EP2415763 A1, 2012 ; Location in patent: Page/Page column 106 ;
  • Route3
    • null|null
      933068-91-8
    • ~79%
    • In-stock
      2-(Aminomethyl)benzofuran|CS-0186434
      37798-05-3

    References

    • Russo, Olivier; Messaoudi, Samir; Hamze, Abdallah; Olivi, Nathanaeel; Peyrat, Jean-Francois; Brion, Jean-Daniel; Sicsic, Sames; Berque-Bestel, Isabelle; Alami, Mouad Tetrahedron, 2007 , vol. 63, # 43 p. 10671 - 10683

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   39.16
  • LogP   1.8915
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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