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CS-W001157 4
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2-Methyl-5-pentanelactam

  • CAS No. 3768-43-2

  • Cat. No. CS-0186670
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methyl-5-pentanelactam|CS-0186670

Structure of 3768-43-2

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General Information

  • CAS No. 3768-43-2
  • Cat. No. CS-0186670
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) 3-Methylpiperidin-2-one
  • SMILES CC1CCCNC1=O

Description

2-Methyl-5-pentanelactam is a cyclic amide featuring a sterically hindered alkyl substituent at the 2-position, enhancing its thermal stability and resistance to hydrolysis. This structural motif enables efficient integration into polyamide backbones and facilitates controlled polymerization under mild conditions.

Application

2-Methyl-5-pentanelactam serves as a versatile scaffold for the synthesis of substituted pyrrolidines and related nitrogen-containing heterocycles. Its cyclic amide structure exhibits good bench stability and facilitates selective functionalization at the 2-methyl and carbonyl positions, enabling efficient access to bioactive analogs through standard amidation, reduction, and ring-opening reactions.

Synthesis

  • Route1
    • In-stock
      Ethyl nicotinate|CS-W014344
      614-18-6
    • ~%
    • In-stock
      2-Methyl-5-pentanelactam|CS-0186670
      3768-43-2
    • null|null
      71962-74-8

    References

    • Folkers; Adkins Journal of the American Chemical Society, 1932 , vol. 54, p. 1146
  • Route2
    • null|null
      113789-89-2
    • ~71%
    • In-stock
      2-Methyl-5-pentanelactam|CS-0186670
      3768-43-2

    References

    • Khoukhi, N.; Vaultier, M.; Carrie, R. Tetrahedron, 1987 , vol. 43, # 8 p. 1811 - 1822
  • Route3
    • null|null
      626-56-2
    • ~%
    • In-stock
      2-Methyl-5-pentanelactam|CS-0186670
      3768-43-2
    • In-stock
      5-Methylpiperidin-2-one|CS-0009361
      3298-16-6

    References

    • Khusnutdinova, Julia R.; Ben-David, Yehoshoa; Milstein, David Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 2998 - 3001

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.5325
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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