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CS-W001157 4
Total: USD 88.00

4-Chloro-6-(trifluoromethyl)pyrimidine

  • CAS No. 37552-81-1

  • Cat. No. CS-W003217
  • Purity≥97%
  • MDL No.MFCD04972771

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-(trifluoromethyl)pyrimidine|CS-W003217

Structure of 37552-81-1

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General Information

  • CAS No. 37552-81-1
  • Cat. No. CS-W003217
  • Purity ≥97%
  • MDL No. MFCD04972771
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂ClF₃N₂
  • Molecular Weight 182.53
  • Synonym(s) IFLAB-BB F2124-0884
  • SMILES FC(c1ncnc(c1)Cl)(F)F

Description

4-Chloro-6-(trifluoromethyl)pyrimidine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the chloro substituent enables facile cross-coupling. This pyrimidine scaffold serves as a key building block in agrochemical and pharmaceutical synthesis, offering high reactivity under standard conditions.

Application

4-Chloro-6-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chlorine atom at the 4-position facilitates nucleophilic substitution reactions, while the electron-withdrawing trifluoromethyl group enhances reactivity and metabolic stability. The compound exhibits excellent bench stability and is compatible with diverse coupling protocols, making it well-suited for the synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1

    References

    • Schlosser, Manfred; Lefebvre, Olivier; Ondi, Levente European Journal of Organic Chemistry, 2006 , # 6 p. 1593 - 1598

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.1488
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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