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CS-W001157 4
Total: USD 88.00

2,3-Difluorophenol

  • CAS No. 6418-38-8

  • Cat. No. CS-W002054
  • Purity≥98%
  • MDL No.MFCD00010262

*For research and further manufacturing use only, not for direct human use.

2,3-Difluorophenol|CS-W002054

Structure of 6418-38-8

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General Information

  • CAS No. 6418-38-8
  • Cat. No. CS-W002054
  • Purity ≥98%
  • MDL No. MFCD00010262
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₂O
  • Molecular Weight 130.09
  • Synonym(s) Phenol, 2,3-Difluoro-
  • SMILES Fc1c(O)cccc1F

Description

2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate.

Application

2,3-Difluorophenol serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering enhanced metabolic stability and modulated lipophilicity due to its ortho-fluorine substitution pattern. The phenolic hydroxyl group enables direct functionalization or derivatization, while the difluoro substitution facilitates regioselective electrophilic aromatic substitution and provides favorable electronic effects for coupling reactions. Its bench-stable nature and compatibility with standard synthetic protocols make it a practical choice for constructing bioactive heterocyclic scaffolds and fluorinated aromatic intermediates.

Synthesis

  • Route1

    References

    • Dong, Chu Chuan; Styring, Peter; Goodby, John W.; Chan, Lawrence K. M. Journal of Materials Chemistry, 1999 , vol. 9, # 8 p. 1669 - 1677
  • Route2
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      2,3-Difluorophenol|CS-W002054
      6418-38-8

    References

    • Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 2041 - 2054
  • Route3

    References

    • Advanced Synthesis and Catalysis, , vol. 347, # 7-8 p. 1027 - 1034

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H226-H302-H315-H319-H335-H411
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P391-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.6704
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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