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CS-W001157 4
Total: USD 88.00

Pyrido[3,2-d]pyrimidin-4(3H)-one

  • CAS No. 37538-67-3

  • Cat. No. CS-0037690
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Pyrido[3,2-d]pyrimidin-4(3H)-one|CS-0037690

Structure of 37538-67-3

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General Information

  • CAS No. 37538-67-3
  • Cat. No. CS-0037690
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O
  • Molecular Weight 147.13
  • Synonym(s) Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI)
  • SMILES C1=CC2=C(C(=NC=N2)O)N=C1

Description

Pyrido[3,2-d]pyrimidin-4(3H)-one delivers a rigid, electron-deficient heterocyclic scaffold ideal for medicinal chemistry applications. This planar core integrates seamlessly into kinase inhibitors and nucleoside analogs, offering enhanced binding affinity and metabolic stability under physiological conditions.

Application

Pyrido[3,2-d]pyrimidin-4(3H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient construction of bioactive molecules through standard functionalization at C2, C6, and C8 positions. Its inherent stability and compatibility with diverse coupling reactions facilitate rapid analog synthesis. The compound functions as a core building block for kinase inhibitors and nucleoside derivatives, offering predictable reactivity and ease of purification in routine bench-scale applications.

Synthesis

  • Route1
    • null|null
      122-51-0
    • In-stock
      6-Chloro-3-nitropicolinamide|CS-0062161
      171178-21-5
    • ~87%
    • In-stock
      Pyrido[3,2-d]pyrimidin-4(3H)-one|CS-0037690
      37538-67-3

    References

    • Warner-Lambert Company Patent: US5654307 A1, 1997 ; US 5654307 A
  • Route2

    References

    • Journal of the Chemical Society, , p. 1045,1053
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 39, # 9 p. 1823 - 1835

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.9
  • LogP   0.7304
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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