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CS-W001157 4
Total: USD 88.00

2-Chloro-3-fluoro-6-methylpyridine

  • CAS No. 374633-32-6

  • Cat. No. CS-W008967
  • Purity≥97%
  • MDL No.MFCD03095216

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-fluoro-6-methylpyridine|CS-W008967

Structure of 374633-32-6

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General Information

  • CAS No. 374633-32-6
  • Cat. No. CS-W008967
  • Purity ≥97%
  • MDL No. MFCD03095216
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClFN
  • Molecular Weight None
  • Synonym(s) 2-Chloro-3-fluoro-6-picoline
  • SMILES CC1=CC=C(F)C(Cl)=N1

Description

2-Chloro-3-fluoro-6-methylpyridine is a halogenated pyridine derivative featuring strategically positioned chlorine, fluorine, and methyl groups. This substitution pattern imparts enhanced electrophilicity and regioselective reactivity in cross-coupling processes. The molecule exhibits bench-stable handling characteristics and integrates readily into complex heterocyclic scaffolds during pharmaceutical synthesis.

Application

2-Chloro-3-fluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The ortho-chloro and meta-fluoro substituents allow for selective functionalization, while the methyl group enhances metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability and facilitates efficient synthesis of substituted pyridine scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.18252
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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