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CS-W001157 4
Total: USD 88.00

2-Methyl-6-(trifluoromethyl)pyridine

  • CAS No. 1620-72-0

  • Cat. No. CS-0102124
  • Purity≥97%
  • MDL No.MFCD07774130

*For research and further manufacturing use only, not for direct human use.

2-Methyl-6-(trifluoromethyl)pyridine|CS-0102124

Structure of 1620-72-0

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General Information

  • CAS No. 1620-72-0
  • Cat. No. CS-0102124
  • Purity ≥97%
  • MDL No. MFCD07774130
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃N
  • Molecular Weight None
  • Synonym(s) Pyridine, 2-methyl-6-(trifluoromethyl)-
  • SMILES FC(C1=CC=CC(C)=N1)(F)F

Description

2-Methyl-6-(trifluoromethyl)pyridine features a trifluoromethyl group at the pyridine ring's para position, enhancing electron-withdrawal and metabolic stability. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, offering improved bioavailability and resistance to oxidative degradation in synthetic applications.

Application

2-Methyl-6-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocycles via electrophilic substitution and transition-metal-catalyzed coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides a site for further derivatization. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, facilitating its use in API development and drug discovery workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.40882
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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