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CS-W001157 4
Total: USD 88.00

5-Methyl-2-(trifluoromethyl)pyridine

  • CAS No. 1620-71-9

  • Cat. No. CS-W022411
  • Purity≥98%
  • MDL No.MFCD07774131

*For research and further manufacturing use only, not for direct human use.

5-Methyl-2-(trifluoromethyl)pyridine|CS-W022411

Structure of 1620-71-9

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General Information

  • CAS No. 1620-71-9
  • Cat. No. CS-W022411
  • Purity ≥98%
  • MDL No. MFCD07774131
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃N
  • Molecular Weight 161.12
  • Synonym(s) CHEMPACIFIC 38184
  • SMILES FC(C1=NC=C(C)C=C1)(F)F

Description

5-Methyl-2-(trifluoromethyl)pyridine is a bench-stable, electron-deficient heterocycle featuring a trifluoromethyl group at the 2-position and a methyl substituent at the 5-position. This combination imparts enhanced lipophilicity and metabolic stability, making it an effective building block for pharmaceutical intermediates and agrochemicals. The molecule integrates readily into C–H functionalization and cross-coupling reactions under mild conditions.

Application

5-Methyl-2-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and catalysis, leveraging the combined electronic effects of methyl and trifluoromethyl groups to modulate reactivity and metabolic stability. Its bench-stable nature and compatibility with standard cross-coupling protocols facilitate efficient synthesis of functionalized heterocycles and API intermediates.

Synthesis

  • Route1
    • In-stock
      2-Bromo-5-methylpyridine|CS-W007353
      3510-66-5
    • null|null
      77152-08-0
    • ~77%
    • In-stock
      5-Methyl-2-(trifluoromethyl)pyridine|CS-W022411
      1620-71-9

    References

    • Lishchynskyi, Anton; Novikov, Maxim A.; Martin, Eddy; Escudero-Adan, Eduardo C.; Novak, Petr; Grushin, Vladimir V. Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11126 - 11146

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.40882
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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