5-(Chloromethyl)-2-(trifluoromethyl)pyridine

Name: 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
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CAS No. 386715-33-9
Cat. No. CS-W005537
Purity≥97%
MDL No.MFCD01862650

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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5-(Chloromethyl)-2-(trifluoromethyl)pyridine|CS-W005537

Structure of 386715-33-9

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General Information

CAS No. 386715-33-9
Cat. No. CS-W005537
Purity ≥97%
MDL No. MFCD01862650
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClF₃N
Molecular Weight 195.57
Synonym(s) Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)-
SMILES FC(C1=NC=C(CCl)C=C1)(F)F

Description

This pyridine derivative features a chloromethyl group at the 5-position and a trifluoromethyl substituent at the 2-position, creating a uniquely reactive and electron-deficient scaffold. The trifluoromethyl moiety enhances metabolic stability and lipophilicity, while the pendant chloromethyl group enables facile nucleophilic substitution for conjugation or functionalization in synthetic workflows. This combination delivers a robust platform for medicinal chemistry and materials science applications.

Application

5-(Chloromethyl)-2-(trifluoromethyl)pyridine serves as a versatile building block for C–H functionalization and cross-coupling reactions, enabling efficient access to substituted pyridine scaffolds. The chloromethyl group facilitates nucleophilic substitution under mild conditions, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity—key attributes in medicinal chemistry. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅱ
Hazard Statements : H302+H312+H332-H314
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 2.8392
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-(Chloromethyl)-2-(trifluoromethyl)pyridine

CAS No. 386715-33-9

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