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CS-W001157 4
Total: USD 88.00

4,6-Dibromopyrimidine

  • CAS No. 36847-10-6

  • Cat. No. CS-W008458
  • Purity≥95%
  • MDL No.MFCD00233946

*For research and further manufacturing use only, not for direct human use.

4,6-Dibromopyrimidine|CS-W008458

Structure of 36847-10-6

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General Information

  • CAS No. 36847-10-6
  • Cat. No. CS-W008458
  • Purity ≥95%
  • MDL No. MFCD00233946
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Br₂N₂
  • Molecular Weight None
  • Synonym(s) 4,6-Dibromopyrimydine
  • SMILES BrC1=NC=NC(=C1)Br

Description

Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced lung inflammation, aminophylline decreases levels of IL-5, IL-8, and eosinophils. It is mostly used to prepare solutions for intravenous injections.

Application

4,6-Dibromopyrimidine serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of substituted pyrimidines via palladium-catalyzed cross-coupling reactions. Its well-defined reactivity profile facilitates sequential functionalization at C4 and C6 positions, offering high regiocontrol and compatibility with diverse nucleophiles. The compound exhibits excellent bench stability and ease of purification, making it a practical choice for medicinal chemistry campaigns and heterocyclic scaffold development.

Synthesis

  • Route1

    References

    • Schomaker; Delia Journal of Organic Chemistry, 2001 , vol. 66, # 21 p. 7125 - 7128

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P301+P310-P305+P351+P338-P310-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.0016
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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