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CS-W001157 4
Total: USD 88.00

4-(4-Fluorophenoxy)aniline

  • CAS No. 36160-82-4

  • Cat. No. CS-0186870
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(4-Fluorophenoxy)aniline|CS-0186870

Structure of 36160-82-4

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General Information

  • CAS No. 36160-82-4
  • Cat. No. CS-0186870
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀FNO
  • Molecular Weight 203.21
  • Synonym(s) 4-(4-FLUOROPHENOXY)BENZENAMINE
  • SMILES C1=C(C=CC(=C1)OC2=CC=C(C=C2)N)F

Description

4-(4-Fluorophenoxy)aniline features a fluorinated aromatic ether linkage fused to an aniline scaffold, delivering enhanced electron density and metabolic stability. This structure enables efficient incorporation into pharmaceutical intermediates and functional materials, particularly in kinase inhibitor scaffolds and OLED components.

Synthesis

  • Route1
    • 1-Fluoro-4-(4-nitrophenoxy)benzene|CS-0192925
      2561-25-3
    • ~97%
    • In-stock
      4-(4-Fluorophenoxy)aniline|CS-0186870
      36160-82-4

    References

    • PURDUE PHARMA L.P.; NI, Chiyou; SHAO, Bin; TAFESSE, Laykea; YAO, Jiangchao; YU, Jianming; ZHOU, Xiaoming Patent: WO2012/35421 A2, 2012 ; Location in patent: Page/Page column 179 ; WO 2012/035421 A2
  • Route2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 12, # 16 p. 4477 - 4492
  • Route3

    References

    • Bioorganic and Medicinal Chemistry, , vol. 12, # 16 p. 4477 - 4492

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   3.2002
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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