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CS-W001157 4
Total: USD 88.00

4-(3,4-Difluorophenoxy)aniline

  • CAS No. 383126-84-9

  • Cat. No. CS-0323309
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(3,4-Difluorophenoxy)aniline|CS-0323309

Structure of 383126-84-9

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General Information

  • CAS No. 383126-84-9
  • Cat. No. CS-0323309
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉F₂NO
  • Molecular Weight 221.20
  • Synonym(s) 4-(3,4-DIFLUOROPHENOXY)-BENZENAMINE
  • SMILES C1=C(C=CC(=C1)OC2=CC(=C(C=C2)F)F)N

Description

4-(3,4-Difluorophenoxy)aniline features a fluoro-substituted aromatic ether linkage paired with an aniline handle, delivering enhanced electron density and metabolic stability. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitors and CNS-targeted pharmaceuticals. The para-aniline group enables efficient coupling reactions under standard conditions.

Application

4-(3,4-Difluorophenoxy)aniline serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its dual functionality—phenolic ether and primary aromatic amine—facilitates diverse coupling reactions and derivatization strategies. The molecule exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   3.3393
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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