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CS-W001157 4
Total: USD 88.00

4,5-Dimethylthiazole

  • CAS No. 3581-91-7

  • Cat. No. CS-W011256
  • Purity≥98%
  • MDL No.MFCD00005336

*For research and further manufacturing use only, not for direct human use.

4,5-Dimethylthiazole|CS-W011256

Structure of 3581-91-7

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General Information

  • CAS No. 3581-91-7
  • Cat. No. CS-W011256
  • Purity ≥98%
  • MDL No. MFCD00005336
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇NS
  • Molecular Weight 113.18
  • Synonym(s) None
  • SMILES CC1=C(C)SC=N1

Description

4,5-Dimethylthiazole features a heterocyclic core with two methyl substituents at the 4- and 5-positions, enhancing electron density and stability. This bench-stable compound serves as a key scaffold in medicinal chemistry and synthetic methodology, offering predictable reactivity for C–H functionalization and transition-metal-catalyzed coupling processes.

Application

4,5-Dimethylthiazole serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its electron-rich core facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions. The methyl groups enhance metabolic stability and modulate lipophilicity, while the thiazole ring provides robustness under standard synthetic conditions. This compound enables efficient access to bioactive scaffolds with demonstrated utility in kinase inhibitor and antimicrobial agent development.

Synthesis

  • Route1
    • null|null
      77287-34-4
    • In-stock
      3-Bromobutan-2-one,98%(stabilized with CaCO3)|CS-0130132
      814-75-5
    • ~41%
    • In-stock
      4,5-Dimethylthiazole|CS-W011256
      3581-91-7

    References

    • Karimian, Khashayar; Mohtarami, Fatemeh; Askari, Massoud Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1981 , p. 1538 - 1543
  • Route2
    • null|null
      3332-09-0
    • ~%
    • In-stock
      4,5-Dimethylthiazole|CS-W011256
      3581-91-7
    • 4-Ethylthiazole|CS-0448330
      17626-72-1

    References

    • Heterocycles, , vol. 22, # 9 p. 1947 - 1949
  • Route3

    References

    • Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Ohsawa, Akio Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1547 - 1549

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H302-H315-H318-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.75994
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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