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CS-W001157 4
Total: USD 88.00

4-Methylthiazole-5-carbaldehyde

  • CAS No. 82294-70-0

  • Cat. No. CS-W011148
  • Purity≥95%
  • MDL No.MFCD07368277

*For research and further manufacturing use only, not for direct human use.

4-Methylthiazole-5-carbaldehyde|CS-W011148

Structure of 82294-70-0

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General Information

  • CAS No. 82294-70-0
  • Cat. No. CS-W011148
  • Purity ≥95%
  • MDL No. MFCD07368277
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NOS
  • Molecular Weight 127.16
  • Synonym(s) 5-Formyl-4-methylthiazole
  • SMILES CC1=C(SC=N1)C=O

Description

4-Methylvaleric acid has been used in asymmetric synthesis of (4S)-4-isopropyl-3-[(2?S)-2?,4?-dimethyl-valeryl)]-2-oxazolidinone. It is a versatile building block used in the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and antagonists. It is involved in the synthesis of novel series of high affinity, functionally potent antagonists of the CCR1 receptor.

Application

4-Methylthiazole-5-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds. Its aldehyde functionality facilitates nucleophilic addition, reductive amination, and condensation reactions, while the methyl group provides steric and electronic modulation. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for modular synthesis workflows in API development and catalyst design.

Synthesis

  • Route1
    • 2-(4-Methylthiazol-5-yl)ethanol  Vitamin Impurity|CS-0167056
      137-00-8
    • ~52%
    • In-stock
      4-Methylthiazole-5-carbaldehyde|CS-W011148
      82294-70-0

    References

    • White, Robert L.; Spenser, Ian D. Journal of the American Chemical Society, 1982 , vol. 104, # 18 p. 4934 - 4943
  • Route2

    References

    • WO2005/100330 A1, ; Page/Page column 11 ;
  • Route3

    References

    • Hagiya, Kazutake; Mitsui, Sunao; Taguchi, Hiroaki Synthesis, 2003 , # 6 p. 823 - 828

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.26402
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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