N-Carbobenzoxy-L-homoserine

Name: N-Carbobenzoxy-L-homoserine
Brand: ChemScene
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CAS No. 35677-88-4
Cat. No. CS-0062253
Purity≥97%
MDL No.MFCD00056718

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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General Information

CAS No. 35677-88-4
Cat. No. CS-0062253
Purity ≥97%
MDL No. MFCD00056718
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₅NO₅
Molecular Weight 253.25
Synonym(s) N-(Benzyloxycarbonyl)-L-homoserine
SMILES OCC[C@@H](C(O)=O)NC(OCC1=CC=CC=C1)=O

Description

N-Carbobenzoxy-L-homoserine features a protected amino group and a reactive hydroxyl side chain, enabling direct incorporation into peptide synthesis workflows. The benzyloxycarbonyl (Cbz) moiety ensures stability during handling and reaction sequencing. This derivative serves as a key precursor for homoserine-containing peptides in medicinal chemistry and bioconjugation applications.

Application

N-Carbobenzoxy-L-homoserine serves as a key building block in peptide synthesis and heterocyclic chemistry, offering a stable, bench-ready precursor for L-homoserine-derived scaffolds. Its carboxybenzoyl (Cbz) group provides orthogonal protection for the amine, enabling selective deprotection and coupling under standard conditions. The molecule facilitates efficient construction of β-hydroxy amino acid motifs and supports diverse functionalization, including esterification and cyclization reactions, with high reproducibility in synthetic workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 95.86
LogP 0.7484
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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N-Carbobenzoxy-L-homoserine

CAS No. 35677-88-4

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