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CS-W001157 4
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(2-Methoxypyridin-3-yl)methanamine

  • CAS No. 354824-19-4

  • Cat. No. CS-W021066
  • Purity≥97%
  • MDL No.MFCD09740382

*For research and further manufacturing use only, not for direct human use.

(2-Methoxypyridin-3-yl)methanamine|CS-W021066

Structure of 354824-19-4

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General Information

  • CAS No. 354824-19-4
  • Cat. No. CS-W021066
  • Purity ≥97%
  • MDL No. MFCD09740382
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 3-Pyridinemethanamine,2-methoxy-(9CI)
  • SMILES NCC1=CC=CN=C1OC

Description

This bench-stable amine features a pyridyl core with a methoxy group at the 2-position and a primary amine at the 3-yl methyl substituent. The electron-donating methoxy enhances nucleophilicity, while the nitrogen-rich scaffold enables integration into heterocyclic systems. Ideal for coupling reactions in medicinal chemistry and catalyst design.

Application

(2-Methoxypyridin-3-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard amine functionalization. Its ortho-methoxy group provides enhanced solubility and modulates electronic properties, while the primary amine facilitates conjugation reactions, reductive amination, and coupling protocols. Bench-stable and readily purified by column chromatography, it functions effectively in multistep synthesis of bioactive molecules.

Synthesis

  • Route1

    References

    • PHARMACOPEIA DRUG DISCOVERY, INC. Patent: WO2006/108103 A1, 2006 ; Location in patent: Page/Page column 32 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.5489
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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