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CS-W001157 4
Total: USD 88.00

4-Bromoquinazoline

  • CAS No. 354574-59-7

  • Cat. No. CS-W022124
  • Purity≥95%
  • MDL No.MFCD10697879

*For research and further manufacturing use only, not for direct human use.

4-Bromoquinazoline|CS-W022124

Structure of 354574-59-7

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General Information

  • CAS No. 354574-59-7
  • Cat. No. CS-W022124
  • Purity ≥95%
  • MDL No. MFCD10697879
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂
  • Molecular Weight 209.04
  • Synonym(s) Quinazoline,4-bromo
  • SMILES BrC1=C2C=CC=CC2=NC=N1

Description

4-Bromoquinazoline serves as a key heterocyclic building block in medicinal chemistry, featuring a bromine atom at the 4-position that enables facile functionalization via cross-coupling reactions. The quinazoline core provides a rigid, electron-deficient scaffold ideal for kinase inhibitor development and pharmaceutical lead optimization under standard bench conditions.

Application

4-Bromoquinazoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. Its bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the quinazoline core offers inherent stability and compatibility with diverse functional groups. This compound facilitates efficient access to kinase inhibitor frameworks and other pharmaceutical intermediates under standard reaction conditions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.3923
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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