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CS-W001157 4
Total: USD 88.00

3-Methoxy-2-thiophenecarboxaldehyde

  • CAS No. 35134-07-7

  • Cat. No. CS-0034119
  • Purity≥97%
  • MDL No.MFCD01571098

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-2-thiophenecarboxaldehyde|CS-0034119

Structure of 35134-07-7

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General Information

  • CAS No. 35134-07-7
  • Cat. No. CS-0034119
  • Purity ≥97%
  • MDL No. MFCD01571098
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆O₂S
  • Molecular Weight 142.18
  • Synonym(s) 3-Methoxythiophene-2-carbaldehyde
  • SMILES O=CC1=C(OC)C=CS1

Description

3-Methoxy-2-thiophenecarboxaldehyde features a thiophene ring fused with an electron-rich methoxy group and a reactive aldehyde handle. This combination enables direct incorporation into heterocyclic scaffolds, offering enhanced solubility and stability under standard bench conditions for synthetic applications in medicinal chemistry and materials science.

Application

3-Methoxy-2-thiophenecarboxaldehyde serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted thiophene derivatives via standard coupling and functional group transformation protocols. Its aldehyde functionality facilitates nucleophilic additions and condensation reactions, while the methoxy group provides moderate electron donation and enhanced stability under typical reaction conditions. The molecule exhibits favorable bench stability and purification characteristics, making it well-suited for iterative synthetic campaigns in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • In-stock
      3-Methoxythiophene|CS-W008023
      17573-92-1
    • null|null
      68-12-2
    • ~70%
    • In-stock
      3-Methoxy-2-thiophenecarboxaldehyde|CS-0034119
      35134-07-7

    References

    • Janssen Pharmaceutica N.V. Patent: WO2004/18483 A1, 2004 ; Location in patent: Page 31 ; WO 2004/018483 A1
  • Route2
    • In-stock
      3-Methoxythiophene|CS-W008023
      17573-92-1
    • null|null
      109-72-8
    • ~%
    • In-stock
      3-Methoxy-2-thiophenecarboxaldehyde|CS-0034119
      35134-07-7

    References

    • EP1149092 B1, ; Page/Page column 32 ;
  • Route3

    References

    • US6184245 B2, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.5692
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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