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CS-W001157 4
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Methyl 3-methoxythiophene-2-carboxylate

  • CAS No. 62353-75-7

  • Cat. No. CS-0042414
  • Purity≥98%
  • MDL No.MFCD00102115

*For research and further manufacturing use only, not for direct human use.

Methyl 3-methoxythiophene-2-carboxylate|CS-0042414

Structure of 62353-75-7

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General Information

  • CAS No. 62353-75-7
  • Cat. No. CS-0042414
  • Purity ≥98%
  • MDL No. MFCD00102115
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₃S
  • Molecular Weight 172.20
  • Synonym(s) METHYL 3-METHOXY-2-THIOPHENECARBOXYLATE
  • SMILES O=C(C1=C(OC)C=CS1)OC

Description

Methyl 3-methoxythiophene-2-carboxylate features a thiophene core with complementary methoxy and ester functionalities, enabling direct integration into cross-coupling and cyclization sequences. This bench-stable heterocycle delivers regioselective reactivity under standard conditions, serving as a key building block for functionalized thienyl architectures in synthetic medicinal chemistry and materials science.

Application

Methyl 3-methoxythiophene-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to functionalized thiophene scaffolds. Its methoxy and ester groups provide orthogonal reactivity for downstream transformations, including palladium-catalyzed cross-couplings and selective reductions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic campaigns in medicinal chemistry and materials science.

Synthesis

  • Route1
    • In-stock
      Methyl 3-hydroxythiophene-2-carboxylate|CS-M0427
      5118-06-9
    • null|null
      74-88-4
    • ~%
    • In-stock
      Methyl 3-methoxythiophene-2-carboxylate|CS-0042414
      62353-75-7

    References

    • Bioorganic and Medicinal Chemistry, , vol. 11, # 20 p. 4333 - 4340
  • Route2
    • In-stock
      Methyl 3-hydroxythiophene-2-carboxylate|CS-M0427
      5118-06-9
    • null|null
      77-78-1
    • ~91%
    • In-stock
      Methyl 3-methoxythiophene-2-carboxylate|CS-0042414
      62353-75-7

    References

    • Aitken, R. Alan; Bibby, Michael C.; Bielefeldt, Florian; Double, John A.; Laws, Andrea L.; Mathieu, Anne-Laure; Ritchie, Robert B.; Wilson, David W. J. Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 405 - 411
  • Route3
    • null|null
      186581-53-3
    • 3-Hydroxythiophene-2-carboxylic acid|CS-0096798
      5118-07-0
    • ~%
    • In-stock
      Methyl 3-methoxythiophene-2-carboxylate|CS-0042414
      62353-75-7

    References

    • Chemische Berichte, , vol. 87, p. 848,855 Arkiv foer Kemi, , vol. 12, p. 239,243

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.5433
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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