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CS-W001157 4
Total: USD 88.00

7-Methoxy-2,3-dihydro-1H-inden-1-one

  • CAS No. 34985-41-6

  • Cat. No. CS-W013258
  • Purity≥98%
  • MDL No.MFCD07784339

*For research and further manufacturing use only, not for direct human use.

7-Methoxy-2,3-dihydro-1H-inden-1-one|CS-W013258

Structure of 34985-41-6

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General Information

  • CAS No. 34985-41-6
  • Cat. No. CS-W013258
  • Purity ≥98%
  • MDL No. MFCD07784339
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₂
  • Molecular Weight 162.19
  • Synonym(s) 7-Methoxy-1-indanone
  • SMILES O=C1CCC2=C1C(OC)=CC=C2

Description

7-Methoxy-2,3-dihydro-1H-inden-1-one features a fused bicyclic core with a methoxy group at the 7-position, enhancing solubility and electronic modulation. This bench-stable ketone serves as a key intermediate in synthesizing indenone-based pharmaceuticals and functional materials, offering predictable reactivity in nucleophilic addition and coupling processes.

Application

7-Methoxy-2,3-dihydro-1H-inden-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indane scaffolds. Its bench-stable ketone functionality tolerates a range of reaction conditions and facilitates downstream transformations such as nucleophilic additions, reductive amination, and transition-metal-catalyzed couplings. The methoxy group enhances solubility and provides a handle for selective derivatization, making it valuable in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 13 p. 3415 - 3418
  • Route2
    • null|null
      201230-82-2
    • (3-Methoxy-Phenylethynyl)-trimethyl-silane|CS-0772148
      40230-92-0
    • ~27%
    • In-stock
      7-Methoxy-2,3-dihydro-1H-inden-1-one|CS-W013258
      34985-41-6
    • In-stock
      5-Methoxy-1-indanone|CS-W001196
      5111-70-6

    References

    • Journal of Organic Chemistry, , vol. 58, # 20 p. 5386 - 5392
  • Route3
    • In-stock
      7-Hydroxy-2,3-dihydro-1H-inden-1-one|CS-W008299
      6968-35-0
    • null|null
      74-88-4
    • ~61%
    • In-stock
      7-Methoxy-2,3-dihydro-1H-inden-1-one|CS-W013258
      34985-41-6

    References

    • Tetrahedron Asymmetry, , vol. 14, # 4 p. 481 - 487

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317-H319
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.8241
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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