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7-Chloro-2,3-dihydroinden-1-one

  • CAS No. 34911-25-6

  • Cat. No. CS-B0435
  • Purity≥97%
  • MDL No.MFCD06796576

*For research and further manufacturing use only, not for direct human use.

7-Chloro-2,3-dihydroinden-1-one|CS-B0435

Structure of 34911-25-6

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General Information

  • CAS No. 34911-25-6
  • Cat. No. CS-B0435
  • Purity ≥97%
  • MDL No. MFCD06796576
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClO
  • Molecular Weight 166.60
  • Synonym(s) 7-Chloro-1-indanone
  • SMILES O=C(CC1)C(C1=CC=C2)=C2Cl

Description

7-Chloro-2,3-dihydroinden-1-one is a bench-stable, electron-deficient heterocyclic ketone featuring a fused tricyclic scaffold. This compound integrates readily into synthetic sequences requiring activated carbonyl functionality and serves as a key intermediate in the construction of complex polycyclic architectures.

Application

7-Chloro-2,3-dihydroinden-1-one serves as a versatile building block in medicinal chemistry and synthetic organic research. Its electrophilic carbonyl group enables efficient nucleophilic addition and subsequent ring closure reactions, facilitating the construction of complex heterocyclic scaffolds. The chloro substituent enhances reactivity and provides a handle for further functionalization. This compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E. Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
  • Route2
    • 4-Amino-7-chloro-2,3-dihydro-1H-inden-1-one|CS-0566328
      408314-52-3
    • ~%
    • In-stock
      7-Chloro-2,3-dihydroinden-1-one|CS-B0435
      34911-25-6

    References

    • Journal of the American Chemical Society, , vol. 74, p. 536
  • Route3
    • null|null
      860356-79-2
    • ~%
    • In-stock
      7-Chloro-2,3-dihydroinden-1-one|CS-B0435
      34911-25-6

    References

    • Journal of the American Chemical Society, , vol. 74, p. 536

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4689
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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