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CS-W001157 4
Total: USD 88.00

2-(Piperidin-1-yl)benzaldehyde

  • CAS No. 34595-26-1

  • Cat. No. CS-W021453
  • Molecule weight189.25
  • Purity≥97%
  • MDL No.MFCD03419311

*For research and further manufacturing use only, not for direct human use.

2-(Piperidin-1-yl)benzaldehyde|CS-W021453

Structure of 34595-26-1

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General Information

  • CAS No. 34595-26-1
  • Cat. No. CS-W021453
  • Purity ≥97%
  • MDL No. MFCD03419311
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO
  • Molecular Weight 189.25
  • Synonym(s) 2-PIPERIDINOBENZENECARBALDEHYDE
  • SMILES C1=CC=CC(=C1N2CCCCC2)C=O

Description

2-(Piperidin-1-yl)benzaldehyde features a piperidine ring tethered to a benzaldehyde scaffold, delivering enhanced solubility and nucleophilic character. This electron-rich aryl aldehyde integrates readily into multicomponent reactions and serves as a key building block in medicinal chemistry, particularly for ligand development and heterocyclic synthesis under standard conditions.

Application

2-(Piperidin-1-yl)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant scaffolds. The aldehyde functionality facilitates nucleophilic addition and condensation reactions, while the piperidine moiety provides a basic nitrogen for derivatization or metal coordination. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for multistep synthesis and library generation.

Synthesis

  • Route1
    • null|null
      110-89-4
    • In-stock
      2-Fluorobenzaldehyde|CS-W008891
      446-52-6
    • ~95%
    • In-stock
      2-(Piperidin-1-yl)benzaldehyde|CS-W021453
      34595-26-1

    References

    • Jurberg, Igor D.; Peng, Bo; Woestefeld, Eckhard; Wasserloos, Maximilian; Maulide, Nuno Angewandte Chemie - International Edition, 2012 , vol. 51, # 8 p. 1950 - 1953
  • Route2
    • 2-(Piperidin-1-yl)benzonitrile|CS-W016892
      72752-52-4
    • ~62%
    • In-stock
      2-(Piperidin-1-yl)benzaldehyde|CS-W021453
      34595-26-1

    References

    • Grell, Wolfgang; Hurnaus, Rudolf Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
  • Route3
    • null|null
      1361537-94-1
    • ~0%
    • null|null
      136638-69-2
    • In-stock
      2-(Piperidin-1-yl)benzaldehyde|CS-W021453
      34595-26-1

    References

    • Mahoney, Stuart J.; Fillion, Eric Chemistry - A European Journal, 2012 , vol. 18, # 1 p. 68 - 71

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   2.4894
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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