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CS-W001157 4
Total: USD 88.00

2,6-Dichloro-4-fluoroaniline

  • CAS No. 344-19-4

  • Cat. No. CS-W017244
  • Purity≥96%
  • MDL No.MFCD00142845

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloro-4-fluoroaniline|CS-W017244

Structure of 344-19-4

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General Information

  • CAS No. 344-19-4
  • Cat. No. CS-W017244
  • Purity ≥96%
  • MDL No. MFCD00142845
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂FN
  • Molecular Weight 180.00
  • Synonym(s) 2',6'-DICHLORO-4'-FLUOROANILINE
  • SMILES NC1=C(Cl)C=C(F)C=C1Cl

Description

2,6-Dichloro-4-fluoroaniline features a trifunctional aromatic core with chlorine and fluorine substituents positioned for orthogonal reactivity. This electron-deficient aniline derivative enables selective coupling in pharmaceutical intermediates and agrochemical scaffolds. The para-fluoro group enhances metabolic stability, while the ortho-chlorines direct electrophilic substitution patterns. Bench-stable under standard conditions, it integrates readily into complex molecular architectures.

Application

2,6-Dichloro-4-fluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling the construction of diverse heterocyclic scaffolds. Its orthogonal halogenation pattern facilitates selective cross-coupling reactions, while the amine group provides a handle for direct derivatization. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for multi-step synthetic sequences in industrial R&D workflows.

Synthesis

  • Route1
    • null|null
      371-40-4
    • ~%
    • In-stock
      2,6-Dichloro-4-fluoroaniline|CS-W017244
      344-19-4

    References

    • Acta Chimica Academiae Scientiarum Hungaricae, , vol. 10, p. 227,229
  • Route2
    • null|null
      106-49-0
    • ~%
    • In-stock
      2,6-Dichloro-4-fluoroaniline|CS-W017244
      344-19-4

    References

    • Chemical Communications, , vol. 49, # 94 p. 11044 - 11046
  • Route3

    References

    • Chemical Communications, , vol. 49, # 94 p. 11044 - 11046

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H373-H411
Precautionary Statements : P261-P273-P280

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.7147
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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