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CS-W001157 4
Total: USD 88.00

4-Methylpyrimidin-5-amine

  • CAS No. 3438-61-7

  • Cat. No. CS-D1592
  • Purity≥97%
  • MDL No.MFCD09038780

*For research and further manufacturing use only, not for direct human use.

4-Methylpyrimidin-5-amine|CS-D1592

Structure of 3438-61-7

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General Information

  • CAS No. 3438-61-7
  • Cat. No. CS-D1592
  • Purity ≥97%
  • MDL No. MFCD09038780
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) 5-Pyrimidinamine, 4-methyl- (9CI)
  • SMILES NC1=CN=CN=C1C

Description

4-Methylpyrimidin-5-amine features a pyrimidine core with a methyl group at the 4-position and an amino function at the 5-position, delivering enhanced electron density for nucleophilic engagement. This bench-stable heterocycle integrates readily into pharmaceutical scaffolds, offering robust reactivity under standard conditions.

Application

4-Methylpyrimidin-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its amine functionality facilitates direct coupling reactions and derivatization, while the methyl group enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with standard synthetic protocols, including Suzuki-Miyaura and Buchwald-Hartwig couplings. It functions as a key intermediate in the development of kinase inhibitors and other bioactive molecules.

Synthesis

  • Route1

    References

    • Yakugaku Zasshi, , vol. 62, p. 315,333; dtsch. Ref. S. 95, 106 Chem.Abstr., , p. 5150
  • Route2

    References

    • Chemische Berichte, , vol. 34, p. 1242
  • Route3
    • In-stock
      2-Chloro-4-methylpyrimidin-5-amine|CS-W019804
      20090-69-1
    • null|null
      10034-85-2
    • ~%
    • In-stock
      4-Methylpyrimidin-5-amine|CS-D1592
      3438-61-7

    References

    • Chemische Berichte, , vol. 34, p. 1242

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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