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CS-W001157 4
Total: USD 88.00

2,4-Dimethylpyrimidin-5-amine

  • CAS No. 35733-53-0

  • Cat. No. CS-W018724
  • Purity≥97%
  • MDL No.MFCD09608073

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethylpyrimidin-5-amine|CS-W018724

Structure of 35733-53-0

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General Information

  • CAS No. 35733-53-0
  • Cat. No. CS-W018724
  • Purity ≥97%
  • MDL No. MFCD09608073
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) 5-Pyrimidinamine, 2,4-dimethyl- (9CI)
  • SMILES NC1=CN=C(C)N=C1C

Description

2,4-Dimethylpyrimidin-5-amine features a pyrimidine core with methyl groups at the 2- and 4-positions and a primary amine at the 5-position. This electron-rich heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

2,4-Dimethylpyrimidin-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its pyrimidine core exhibits favorable metabolic stability and moderate basicity, facilitating direct incorporation into kinase inhibitors and other pharmaceutical scaffolds. The compound demonstrates excellent bench stability, tolerates a range of functional groups, and participates reliably in standard coupling reactions, making it well-suited for parallel synthesis and lead optimization campaigns.

Synthesis

  • Route1
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      98594-50-4
    • ~%
    • In-stock
      2,4-Dimethylpyrimidin-5-amine|CS-W018724
      35733-53-0

    References

    • Helvetica Chimica Acta, , vol. 41, p. 1806,1812 US2890218 , ;
  • Route2
    • 2,4-Dimethylpyrimidine-5-carboxamide|CS-0045894
      53554-30-6
    • ~%
    • In-stock
      2,4-Dimethylpyrimidin-5-amine|CS-W018724
      35733-53-0

    References

    • Helvetica Chimica Acta, , vol. 41, p. 1806,1812
  • Route3

    References

    • Helvetica Chimica Acta, , vol. 41, p. 1806,1812

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.67564
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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