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CS-W001157 4
Total: USD 88.00

Ethyl 2-(1,1-dioxidothiomorpholino)acetate

  • CAS No. 343334-01-0

  • Cat. No. CS-0451437
  • Molecule weight221.27
  • Purity≥98%
  • MDL No.MFCD02081985

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(1,1-dioxidothiomorpholino)acetate|CS-0451437

Structure of 343334-01-0

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General Information

  • CAS No. 343334-01-0
  • Cat. No. CS-0451437
  • Purity ≥98%
  • MDL No. MFCD02081985
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₄S
  • Molecular Weight 221.27
  • Synonym(s) ETHYL 2-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)ACETATE
  • SMILES CCOC(=O)CN1CCS(=O)(=O)CC1

Description

Ethyl 2-(1,1-dioxidothiomorpholino)acetate features a sulfone-functionalized thiomorpholine ring that imparts enhanced polarity and metabolic stability. This electrophilic ester integrates readily into synthetic sequences requiring sulfur-containing heterocycles, offering improved solubility and robustness under standard conditions.

Application

Ethyl 2-(1,1-dioxidothiomorpholino)acetate serves as a versatile building block in medicinal chemistry, enabling the efficient introduction of the sulfonamide-containing thiomorpholine scaffold. The molecule's bench-stable nature and tolerance to common functional groups facilitate straightforward incorporation into diverse synthetic sequences. Its reactivity supports nucleophilic displacement and subsequent transformations critical for constructing bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • In-stock
      Thiomorpholine 1,1-dioxide|CS-W009111
      39093-93-1
    • null|null
      105-39-5
    • ~%
    • In-stock
      Ethyl 2-(1,1-dioxidothiomorpholino)acetate|CS-0451437
      343334-01-0

    References

    • Journal of the Chemical Society, , p. 2433,2440
  • Route2

    References

    • Journal of the Chemical Society, , vol. 123, p. 2890
  • Route3
    • null|null
      77-77-0
    • H-Gly-Oet|CS-0636597
      459-73-4
    • ~%
    • In-stock
      Ethyl 2-(1,1-dioxidothiomorpholino)acetate|CS-0451437
      343334-01-0

    References

    • Journal of the Chemical Society, , p. 1916

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   63.68
  • LogP   -0.7201
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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