4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide

Name: 4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide
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CAS No. 26475-62-7
Cat. No. CS-0158317
Molecule weight179.24
Purity≥97%
MDL No.MFCD00106415

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide|CS-0158317

Structure of 26475-62-7

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General Information

CAS No. 26475-62-7
Cat. No. CS-0158317
Purity ≥97%
MDL No. MFCD00106415
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₃NO₃S
Molecular Weight 179.24
Synonym(s) 2-(1,1-Dioxothiomorpholino)ethanol
SMILES C(CO)N1CCS(=O)(=O)CC1

Description

4-(2-Hydroxyethyl)thiomorpholine 1,1-dioxide features a polar, bench-stable sulfonamide core with a terminal hydroxyl group enabling conjugation or solubility enhancement. This functionalized thiomorpholine scaffold integrates readily into bioactive molecules, offering improved aqueous solubility and metabolic stability in medicinal chemistry applications.

Application

4-(2-Hydroxyethyl)thiomorpholine 1,1-dioxide serves as a versatile sulfonamide-containing building block in medicinal chemistry, enabling the construction of bioactive heterocycles. Its hydroxyl group offers direct handle for derivatization via esterification or ether formation, while the thiomorpholine dioxide moiety provides enhanced solubility and metabolic stability. The molecule exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating efficient incorporation into complex molecular architectures.

Synthesis

Route1
- 7617-67-6
- 141-43-5
- ~%
- 26475-62-7
References
- Burrows; Reid Journal of the American Chemical Society, 1934 , vol. 56, p. 1720
Route2
- 77-77-0
- 141-43-5
- ~%
- 26475-62-7
References
- Ford-Moore et al. Journal of the Chemical Society, 1946 , p. 819

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 57.61
LogP -1.2909
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Thiomorpholine compounds

Key Words

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4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide

CAS No. 26475-62-7

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