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Structure of 3430-19-1
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5-Methylpyridin-3-amine features a pyridine core with strategically positioned methyl and amino groups, enabling robust coordination in transition metal catalysis. The para-substituted amine enhances nucleophilicity while the methyl group imparts steric stabilization. This bench-stable heterocycle integrates efficiently into ligand frameworks for cross-coupling reactions and serves as a key building block in medicinal chemistry scaffolds.
5-Methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through palladium-catalyzed cross-coupling and electrophilic substitution. Its pyridine core offers moderate basicity and enhanced solubility, while the methyl group provides a site for directed functionalization. The amine functionality facilitates salt formation and conjugation, enhancing its utility in lead optimization and API synthesis.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P280-P302+P352
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Lot numbers can be found on the outside label of a product: